Alisanne was the step-daughter of a powerful merchant named Uther Nere, after her step-father killed her mother, Alisanne swore revenge on him for killing her mother, she tries to contact the Dark Brotherhood to learn from them so she eventually she could kill Uther.
Alisanne eventually becomes the Listener some time during the Great war. In Rain's Hand 4E 187, Alisanne visited the Cheydinhal Sanctuary and spoke with Rasha about the possibility of reinstating training for Shadowscales in Archon, Black Marsh, although they never did, due to the lack of resources. During the hostilities between two rival skooma gangs known as the Claws, and the Eclipse in Bravil, Alisanne was forced to hire mercenaries to protect her home. As the riots escalated, The Lucky Old Lady statue was destroyed, and Alisanne went to the Crypt under The Lucky Old Lady to protect the Night Mother. After the skooma gangs were dealt with, Uther and his men arrive to kill Alisanne and burn the Night Mother's corpse. While she and the agent(if chooses to defend her) hold down his men, Garnag takes the Night Mother to the Cheydinhal Sanctuary. She was burned alive by Uther's mages during the fight while trying to protect the Night Mother's coffin.  It is noted in his journals that Cicero had a great amount of respect for her, even before becoming the Keeper.
- It is not confirmed if Uther was her father or her step-father
- If the agent sides with her or Uther, either way she dies. It is unknown however if Uther survives.