Lis is a seemingly domesticated frostbite spider located in a spider nest within the Dark Brotherhood Sanctuary. It is owned by Gabriella. Lis' name would appear to suggest it is female. The player seems to be unable to inquire anything concerning the spider's relationship to the other Dark Brotherhood members. As a result, Lis' origins, as well as the identity of the one who trained her are unknown. Sometimes when the player first encounters Lis, they may mistake her for a hostile frostbite spider and attack her, causing the Dark Brotherhood to become hostile towards the player.
Lis is killed during the attack on the Dark Brotherhood Sanctuary by the Penitus Oculatus Agents.
- In the small pond in the nest are the skeletal remains of a person named Gaston Bellefort, who was killed by the Dark Brotherhood and fed to Lis.
- If a Dark Brotherhood member witnesses you attacking and or killing Lis, all members will become hostile.
- Lis is unusual compared to her kin, in that she is small, yet carries 2 Frostbite Venoms, something generally only carried by Giant Frostbite Spiders. This may be reference as to how potent her venom is.
- You will not be attacked by the Dark Brotherhood members if you sneak while you kill Lis.