They are said to look like a mix of various creatures. Namely, the Nord Belinka (who had been sent to Craglorn) describes their appearance as "almost as though a scorpion and a Wamasu had a baby." "Mantikora" is the local name, and the creature doesn't seem to be well known elsewhere. The Mantikora appears to be an apex predator, as even other predators are reported to serve as its food source.
Mantikoras are mentioned by Boward, Regent of Wriggling Nightmares, who mentions alchemical experiments involving a Wamasu egg-bearer; the traits of a scorpion matron and a crocodile matriarch; and a Mantikora (of which increasing the power of was the objective). He also wanted to provide the said Mantikora with the Wamasu's charged current ability, in hope of creating a new, "wondrous" creature and thus raising his position in the Scaled Court. Other sources describe it as a cross between a Scorpion and a Wamasu 
The first boss in this quest is a possessed Mantikora, likely possessed by the Celestial Serpent.
Indirect role - Mantikora is in one of the rooms in Skyreach Hold. It is possible to run past them, however.
- The name Mantikora is likely a nod to the Manticore.
- Hrozizolk is capabale of creating Mantikora.