"Arkay has terrible news friend. Your friend, kidnapped!"
Rescue is a repeatable quest offered by Florentius Baenius in Fort Dawnguard. To complete it, rescue a friend or spouse from a Master Vampire in a randomly selected location across Skyrim. The friend in question is anyone that has a friendly disposition towards the Dragonborn, no matter who it is. It's even possible for the kidnapped friend to be a Jarl or children.
Victims that can become followers will not do so for the duration of this quest. Reporting a successful rescue to Florentius removes this restriction.
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Sometimes, if the victim is a spouse, they may remain at their home instead of appearing at the location. If this occurs, check the marital abode or load a previous save. This may fix it and get a new victim.
Sometimes the marker for the quest points to a random location on the outdoor map. If you have already killed the Master Vampire, this indicates the rescuee is now located outside, and is moving (possibly returning to their normal spawn point like a stolen horse does when you dismount it). The good news is that chasing them down is possible, and if you can catch up to them and talk to them, the quest completes normally.
Occasionally, speaking to a spouse after rescuing them will start a new Rescue quest; leading to a new vampire to kill. However, the vampire doesn't actually spawn in the area - leaving the quest unfinishable, and thus making it impossible to get any more quests from any of the Dawnguard's members.
Occasionally, even if the victim is not a spouse, and instead just a friend, they will still call the Dragonborn "my love" when rescued.
Sometimes talking to a random friend starts the quest but the vampire does not spawn so its unfinishable (the chance may increase if a quick save is made before starting the quest then quick load after starting the quest).
If this Quest is done anytime after finishing A Night To Remember, and the dungeon is Morvunskar, there is a possibility that Sanguine spawns and assists the Dragonborn in killing the Vampires.
(Xbox 360 Version)Once you get the quest and travel to the random location, there is a chance that the Master Vampire will not spawn making the quest unfinishable and not allowing anymore quests to be done by the dawnguard.