I've put in over 600 hours into Skyrim so far and I have to say, I love the depth of emotion people can form with their characters and followers. I personally haven't ever had that kind of connection with a follower, but there are some things in the game that have made me stop and think. Certain places have made me wonder; What happened here?
Walking along the beach on the way to the college of Winterhold I noticed what looked like a bear, so I went sneaking over to it and it was a tent. Of course my first thought was "Oh good, some loot." Looking inside I found a bedroll covered in different color mountain flowers and some other odds and ends. It dawned on me that I had stumbled upon some newlyweds honeymoon, but they were nowhere to be found. I looked around the area for hours and I found nothing. I still wonder sometimes... what happened to them?
The other place I found was while I was wandering around the northernedge of the game, just swimming around to see if I could find anything that I hadn't seen before. I found a small island and started exploring. Soon I found a rowboat on the shore and not far away I saw a makeshift flag sticking out of the ground. Next to the flag was a skeleton, and a chest full of gold ignots. Once again I still wonder what happened.