It would appear that Vampires are set to return in The Elder Scrolls V Skyrim.

In previous Elder Scrolls games you became a vampire by contracting a disease called Porphyric Hemophilia which was easily curable in the early stages by much harder to get rid of left untreated.

The news was discovered by Ripten during a hands on session with the game, they stumbled across two Vampires in a cave just outside of town. In previous Elder Scrolls games you could contract the disease and become a Vampire and with them appearing in Skyrim I would expect the same thing to occur.

  i found all this here=