It would appear that Vampires are set to return in The Elder Scrolls V Skyrim.
In previous Elder Scrolls games you became a vampire by contracting a disease called Porphyric Hemophilia which was easily curable in the early stages by much harder to get rid of left untreated.
The news was discovered by Ripten during a hands on session with the game, they stumbled across two Vampires in a cave just outside of town. In previous Elder Scrolls games you could contract the disease and become a Vampire and with them appearing in Skyrim I would expect the same thing to occur.
i found all this here= http://www.xboxdailynews.com/2011/08/26/vampires-return-to-the-elder-scrolls-v-skyrim/#en